Transcriptional Regulatory Cascades in Runx2-Dependent Bone Development
نویسندگان
چکیده
منابع مشابه
MAML1 Enhances the Transcriptional Activity of Runx2 and Plays a Role in Bone Development
Mastermind-like 1 (MAML1) is a transcriptional co-activator in the Notch signaling pathway. Recently, however, several reports revealed novel and unique roles for MAML1 that are independent of the Notch signaling pathway. We found that MAML1 enhances the transcriptional activity of runt-related transcription factor 2 (Runx2), a transcription factor essential for osteoblastic differentiation and...
متن کاملRegulatory cascades involving calmodulin-dependent protein kinases.
Elucidation of the components that comprise signaling cascades in cells is a primary theme in molecular endocrinology. These signal transduction pathways are frequently initiated at the plasma membrane by the interaction of a ligand with a cell surface receptor. This interaction can result in activation of a number of pathways that are initiated by stimulation of signaling proteins such as JAK/...
متن کاملTranscriptional regulatory cascades in development: initial rates, not steady state, determine network kinetics.
A model was built to examine the kinetics of regulatory cascades such as occur in developmental gene networks. The model relates occupancy of cis-regulatory target sites to transcriptional initiation rate, and thence to RNA and protein output. The model was used to simulate regulatory cascades in which genes encoding transcription factors are successively activated. Using realistic parameter ra...
متن کاملA stochastic spectral analysis of transcriptional regulatory cascades.
The past decade has seen great advances in our understanding of the role of noise in gene regulation and the physical limits to signaling in biological networks. Here, we introduce the spectral method for computation of the joint probability distribution over all species in a biological network. The spectral method exploits the natural eigenfunctions of the master equation of birth-death proces...
متن کاملSharks Have Bone and Other Runx2-dependent Skeletal Features
Introduction: Many inherited or trauma-induced conditions, such as cleidocranial dysplasia or non-union fractures, result from inadequate bone formation [1]. Perhaps providing insight into such clinical maladies, bone formation was lost during evolution. Chondrichthyes, fish whose internal skeleton is entirely cartilaginous, evolved from an ancestral vertebrate population that possessed bone. W...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tissue Engineering Part B: Reviews
سال: 2013
ISSN: 1937-3368,1937-3376
DOI: 10.1089/ten.teb.2012.0527